Genetic risk sum score comprised of common polygenic variation is associated with body mass index
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چکیده
منابع مشابه
Body Mass Index Genetic Risk Score and Endometrial Cancer Risk
Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) based on the joint effect of published BMI risk loci were used to explore whether endometrial cancer shares a genetic background with obesity. Genotype and risk factor data we...
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BACKGROUND While the number of established genetic variants associated with adult body mass index (BMI) is growing, the relationships between these variants and growth during childhood are yet to be fully characterised. We examined the association between validated adult BMI associated single nucleotide polymorphisms (SNPs) and growth trajectories across childhood. We investigated the timing of...
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Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...
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ژورنال
عنوان ژورنال: Human Genetics
سال: 2010
ISSN: 0340-6717,1432-1203
DOI: 10.1007/s00439-010-0917-1